SAM-e is a natural compound found in every cell of the human body. It is involved in many biochemical processes, including the synthesis of the neurotransmitters serotonin, dopamine, and norepinephrine. These are important for regulating mood, anxiety, productivity, motivation and a positive outlook.
SAM-e is available as a supplement in the united states and is commonly used to treat a variety of mental health conditions, including depression, anxiety and schizo-affective disorder. It is also a prescription antidepressant in some countries in Europe.
SAM-e has been shown to be effective in the treatment of depression. Several studies have found that SAM-e can be as effective as prescription antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), in improving symptoms of depression and uplifting ones mood.
SAM-e works by increasing the levels of neurotransmitters in the brain that are involved in regulating mood and thought. It also helps to reduce inflammation and oxidative stress, which are known to be contributing factors in depression.
Benefits of SAM-e for Mental Health
In addition to improving symptoms of depression, SAM-e has several other benefits for mental health. These include:
- Anxiety Reduction: SAM-e has been shown to reduce symptoms of anxiety, including worry, nervousness, and tension.
- Cognitive Function Improvement: SAM-e has been found to improve cognitive function, including memory, attention, and concentration, in people with depression.
- Sleep Quality Improvement: SAM-e has been shown to improve sleep quality and reduce sleep disturbances in people with depression.
Function of SAM-e
SAM-e is synthesized from methionine and adenosine triphosphate (ATP) by the enzyme methionine adenosyltransferase (MAT). SAM-e is then used in the synthesis of various compounds, including phosphatidylcholine, creatine, and polyamines, which are essential for the proper functioning of cells.
One of the most important functions of SAM-e is its role in the synthesis of neurotransmitters. SAM-e donates a methyl group to the amino acid tyrosine, which is then converted to L-dopa, a precursor to dopamine. SAM-e also donates a methyl group to serotonin, which is involved in the regulation of mood, appetite, and sleep.
SAM-e also plays a crucial role in the regulation of gene expression. SAM-e donates a methyl group to DNA, which can affect the expression of genes. Methylation of DNA can turn genes on or off, which can affect various cellular processes, including cell growth, differentiation, and apoptosis.
SAM-e also helps to protect cellular membranes from oxidative damage. SAM-e is involved in the synthesis of glutathione, a powerful antioxidant that helps to protect cells from oxidative stress. SAM-e also helps to regulate the levels of reactive oxygen species (ROS) in cells, which can cause cellular damage if not properly controlled.
How SAM-e Works For Depression
SAM-e has been shown to be effective in the treatment of depression. There are several mechanisms of action to explain its antidepressant effects.
One mechanism of action is SAM-e’s ability to increase the levels of neurotransmitters in the brain that are involved in regulating mood. SAM-e donates a methyl group to tyrosine, which is then converted to L-dopa and then to dopamine. SAM-e also donates a methyl group to serotonin, which is involved in the regulation of mood, appetite, and sleep.
SAM-e also helps to reduce inflammation and oxidative stress like I mentioned earlier. This is known to contribute to the development of depression. SAM-e is involved in the synthesis of glutathione, a powerful antioxidant that helps to protect cells from oxidative stress. SAM-e also helps to regulate the levels of ROS in cells, which can cause cellular damage if not properly controlled.
SAM-e has been shown to modulate the activity of various signaling pathways involved in the regulation of mood. SAM-e has been found to increase the expression of brain-derived neurotrophic factor (BDNF), a protein that is involved in the growth and survival of neurons. It has been found to increase the activity of cyclic adenosine monophosphate (cAMP) signaling pathways, which are involved in the regulation of mood.
SAM-e has also been found to modulate the activity of various receptors in the brain. SAM-e has been shown to increase the activity of N-methyl-D-aspartate (NMDA) receptors, which are involved in learning and memory. SAM-e has also been found to increase the activity of gamma-aminobutyric acid (GABA) receptors, which are involved in the regulation of anxiety.
Safety and Side Effects of SAM-e
SAM-e is generally considered safe when taken as directed. However, it may cause some side effects, including nausea, diarrhea, and constipation. It may also interact with certain medications, including antidepressants, so it is important to talk to your healthcare provider before taking SAM-e.
SAM-e is a natural supplement that can be effective in the treatment of depression and uplifting ones mood. It works by increasing the levels of neurotransmitters in the brain that are involved in regulating mood, reducing inflammation and oxidative stress, and improving mental health in many ways. While it may cause some side effects, SAM-e is generally well-tolerated and has fewer side effects than prescription antidepressants do.
If you are considering taking SAM-e for depression or any other condition, be sure to talk to your healthcare practitioner to determine if it is safe and appropriate for you. You can find one here at mytelemedicine 24/7 online.
It’s also worth noting sam-e is a great supplement for undermethylators. You can read more about undermethylation here to become more informed.
S-Adenosyl-L-Methionine (SAMe) – National Center for Complementary and Integrative Health (https://www.nccih.nih.gov/health/s-adenosyl-l-methionine-same)
Mischoulon D, Fava M. Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr. 2002 Nov;76(5):1158S-1161S. doi: 10.1093/ajcn/76/5.1158S. PMID: 12418496.
Bottiglieri T. S-Adenosyl-L-Methionine (SAMe): From the Bench to the Bedside—Molecular Basis of a Pleiotrophic Molecule. Am J Clin Nutr. 2002 Nov;76(5):1151S-1157S. doi: 10.1093/ajcn/76/5.1151S. PMID: 12418495.
Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 1990 May;147(5):591-5. doi: 10.1176/ajp.147.5.591. PMID: 2183619.
Papakostas GI, Mischoulon D, Shyu I, Alpert JE, Fava M. S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. Am J Psychiatry. 2010 Aug;167(8):942-8. doi: 10.1176/appi.ajp.2009.09030306. Epub 2010 Jun 15. PMID: 20551448.Fewer Side Effects: SAM-e is generally well-tolerated and has fewer side effects than prescription antidepressants.