The methylenetetrahydrofolate reductase (MTHFR) gene has different variants such as being homozygous and heterozygous. What you need to know is that MTHFR can have significant reductions in methylation processes and people may benefit from supplementing with activated forms of folate, such as methylfolate, methylcobalamin B12, B6 as P-5-P, along with other methylation nutrients such as TMG or SAMe.
Findings suggest that the MTHFR is associated with increased risk for psychiatric disorders and that DNA methylation as well as folate are important in mental health. Reduction of MTHFR activity or a folate deficiency have been associated with an onset of several psychiatric diseases including schizophrenia, bipolar disorder, depression, autism, anxiety disorders and ADHD.
Please review this article about MTHFR and psychiatric diseases for more information.
If you have this MTHFR genetic mutation you may benefit from methylation support for your mental health condition. Be advised it may be months of consistent supplementation before you feel relief from symptoms. Also, once you feel a benefit, continuous supplementation is advised by most practitioners to keep your methylation functioning for you.
May Come with Side Effects
It is important to get accurate testing done before you decide to supplement with these nutrients. Methylated nutrients are very powerful and may produce unwanted effects such as irritability, anger outbursts, and deterioration instead of improvement. That is because not everyone can tolerate methylated vitamins and that is especially true for people suffering from mental health conditions. People suffering from mental health conditions need methylation balance, but most of what you find on the market for MTHFR and homocysteine are in high potency dosages.
Taking high doses of methylated vitamins and supplements can lead to over methylation. These are commonly found in most multivitamins and homocysteine formulations. This can make symptoms worse and create a sense of overdrive in some individuals.
If you still think you need methylation support for your MTHFR genetic mutation, then try a formulation with split and divided capsule doses. This way, instead of one capsule once a day, you can try a formula that is 4 capsules a day for example. Instead of taking your entire daily dose, try 1/4 of the dosage and supplement with only one capsule for the day. Please be advised to start slow and work with a qualified practitioner that can assess your individualized needs.
Common side effects and symptoms of too much methylation include:
Itchy, crawly skin
If you are still unsure and want genetic testing done – I suggest seeking an Naturopathic Doctor or Nutritionist to get the appropriate testing. You can schedule this anytime online 24/7 at mytelemedicine.
This is the option for inexpensive laboratory testing for those who are without insurance, who have high deductibles, want to have confidentiality, and/or whose doctors won’t prescribe them the lab testing they want to have done.